Product categories:

Loosely defined, our catalog offerings mainly consist of two classes of compounds. The first class comprises various sorts of “templates”, or “scaffolds”. Such templates are often found in the chemical structures of a significant portion of commercial drugs, as well as drug candidates that are still at developing stages. For instance, pyrazolo[1,5-a]pyrimidine scaffold is present in some CNS agents^[1,2], while some compounds containing thieno[3,2-b]pyridine moiety are found to regulate certain kinases, rendering themselves as potential agents for the treatment of various diseases including cancer and osteoporosis^[3,4]. The second class of compounds is what we term as “peripheral fragments”, which medicinal chemists often use to derivatize the templates when designing novel molecules or modifying existing drugs or candidates. An example would be substituted 3-aminopyrazoles, which are found in VX-680 (Vertex Pharmaceuticals) or AZD1152 (AstraZeneca), both an Aurora kinase inhibitor^[5].

Unlike some practices in the current market place, we try to stock most if not all of our catalog offerings. In the meantime, we also allocate a significant portion of our resources to researching and developing new products, hoping to constantly expand our portfolio to meet the increasing needs of our customers. To accomplish this, we also welcome suggestions from researchers since these are the actual folks who practice the art and science of pharmaceutical R&D on a daily basis in this extremely challenging field. They are part of the very force driving the true drug innovation. Such feedbacks are extremely valuable for us in order to better serve them in the long run. So please do contact us.

Reference:

[1] Substituted pyrazolo[1,5-a]pyrimidines as metabolic glutamate antagonists, US20090143580[2]

[2] Pyrazolo[1,5-a]pyrimidine adenosine A2a Receptor antagonists, WO/2006/068954

[3] Synthesis and Src Kinase Inhibitory Activity of 2-Phenyl- and 2-Thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles, Journal of Medicinal Chemistry, 2005, 48, 3891-3902

[4] Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses, US20080312185

[5] Discovery and development of aurora kinase inhibitors as anticancer agents, Journal of Medicinal Chemistry, 2009, 52, 2629-2651